![]() Main Outcomes and Measures Outcome measures were tidal breathing analysis and nitrogen multiple-breath washout test measured at 2 months of age. Data analysis was performed from January 1, 2021, to December 31, 2021.Įxposures Mean, SD, minimum, and maximum temperatures at the mother-child’s residence, estimated using a state-of-the-art spatiotemporally resolved model. Data on temperature exposure, lung function, and covariates were available from 343 mother-child dyads. ![]() Objectives To investigate the association of prenatal and postnatal heat or cold exposure with newborn lung function and identify windows of susceptibility.ĭesign, Setting, and Participants This population-based cohort study (SEPAGES) recruited pregnant women in France between July 8, 2014, and July 24, 2017. Importance Little is known about long-term associations of early-life exposure to extreme temperatures with child health and lung function. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.FRC indicates functional residual capacity and tPTEF/tE, time to peak tidal expiratory flow to total expiratory time. The critical window positions can also vary according to sex. The number of associations presented varies across sex because the table restricts to the statistically significant windows (ie, significant associations are not consistently observed among heat, cold, and each respiratory measurement for both male and female newborns). ![]() Models were adjusted for maternal age at conception, highest level of education of the parents, prepregnancy maternal body mass index, parity, parents’ rhinitis, mode of delivery, breastfeeding, prenatal and/or postnatal tobacco exposure, child sex, child age, child weight and height at the lung function test, season at lung function test, and Normalized Difference Vegetation Index for the year of birth. Nighttime indicates the average of daily minimum temperature overall, average of daily mean temperature daytime, average of daily maximum temperature and variability, SD of daily mean temperature. ![]() Long-term exposure includes the first 35 gestational weeks and the first 4 weeks after delivery short-term exposure includes the 7 days before the lung function test. Bars show the timing of critical windows, with cumulative β (95% CI). ![]()
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